Innovative Devices - Company Profile (Robert A. Casper, Ph.D)

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Principals

Robert A. Casper, Ph.D
David L. Gardner, Ph.D

Gastrointestinal
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InteliSite

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Respiratory Devices

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Phone (919) 781-6315

email
devices@mindspring.com

Principals

Robert A. Casper, Ph.D
5335 Carbonton Road
Sanford, NC 27330
Office Phone: (919) 781-6315

Duke University Durham, NC	Ph.D., Biomedical Engineering	1980
Massachusetts Institute Of Technology Cambridge, Mass.	S.M., Chemical Engineering	1974
N.C. State University Raleigh, NC	B.S., Chemical Engineering	1973

Employment History

Innovative Devices, LLC (Raleigh, NC) Partner Development of metered dose inhaler (MDI) devices and dry powder inhaler (DPI) systems for respiratory administration of therapeutic agents. Aerosol physics and engineering support of medical device development and contract R & D activities. Development and manufacture of InteliSiteā capsule for Phase I human volunteer studies. Intellectual property assessment. Consulting, evaluation and testing in support of 510(k) submissions.
Glaxo Inc., (Research Triangle Park, NC) Associate Director, A & H Pharmaceutical Development Engineering direction of breath-activated inhaler development and advancement to manufacturing Evaluation and support of spacer development for use with conventional MDIs Development of novel 60 & 120 dose dry powder inhaler (patent filed, co-inventor) Technical support for development of ambulatory clinical monitoring unit employing neural networks
Section Head, Biomedical Polymers/Materials Science, Pharmaceutics Division Development of novel primary/secondary packaging in support of formulation development Preparation of Container/Closure section of CMC for regulatory filings Engineering support for the development of piezo-electric based delivery system for respiratory products Development of a novel, radio-activated capsule delivery system for use in determining the site-specific absorption characteristics of new and existing compounds and formulations (2 patents issued, co-inventor) Technical expertise/support for determining formulation/package interactions and impact on long-term stability	1993-1994
Kimberly-Clark Corporation (Roswell, GA) Senior Research Scientist, Corporate Science and Technology Development of biocompatible non-woven materials for use as surgical mesh Development of synthetic vascular grafts and prostheses for use in cardiovascular surgery Technical direction of skin hydration modeling and mass transport characteristics of stratum corneum Development of blue-green algae for attachment to wood pulp in support of emerging agri-chemical business	1985-1987
Southern Research Institute (Birmingham, AL) Head, Biomaterials Section, Applied Sciences Department Responsible for contract support of programs in controlled drug delivery, biomechanics, fertility regulation and biomedical engineering Development of totally resorbable fracture fixation system for orthopaedic and reconstructive surgery (patent issued, co-inventor) Development of biocompatible, visco-elastic materials for use in reconstructive dental surgery Development of biodegradable ear-ventilation tubes and eustachian tube shunts. Development of inexpensive fertility regulation systems for use in emerging countries (patent issued, co-inventor) Development of chemical warfare decontamination system for vehicles and equipment (patent issued, co-inventor) Supervision and direction of research staff including Ph.D.,M.S., and B.S., level functions	1982-1985
Research Biomedical Engineer, Biomaterials Section Applied Sciences Dept. Development of synthetic ligaments and tendons Development of synthetic materials for use as maxillo-facial prostheses for victims of accident and disease Technical/Engineering support for development of fermentation process for gasohol industry Development of conducting polymer system for use in biofeedback applications for the physically handicapped Development of piezo-electric polymers for use in disposable sonar buoy applications for submarine detection	1980-1982

Professional Societies & Affiliations
American Chemical Society
American Association for Aerosol Research
Society for Biomaterials
American Institute for Chemical Engineers
Controlled Release Society
Society for Dental Materials

Honors
Phi Kappa Phi (Scholastic Honor Fraternity)
Phi Eta Sigma (Scholastic Honor Fraternity)
Tau Beta Pi (Engineering Honor Fraternity)
Engineering Honors Program (N.C. State University)
ITT Raymier Scholarship (N.C. State University)
Exxon Fellowship (M.I.T.)
National Research Service Award (Duke University)

Patents

Robert A. Casper, Donald R. Cowsar, Richard L. Dunn, and Richard N. Terry, US Patent #4,589,880, "Disposable Spermicide-Releasing Diaphragm; Contraceptive Made of a Mixture of Polyurethane and Antifertility agent; Sustained Release", 20 May 1986.

Robert A. Casper and Richard L. Dunn, US Patent #4,655,777, "Method of Producing Biodegradable Prosthesis and Products Therefrom; forming composite of Resorbable Fiber in Polymer Matrix", 7 April 1987.

Robert A. Casper, Donald R. Cowsar and Richard L. Dunn, US Patent #4,784,699, "Process for Decontaminating Military Nerve and Blister Agents; Ozone or Chlorine Dioxide Oxidizers for Chemical Warfare Agents", 5 November 1988.

Robert A. Casper, Warren J. Jochem, Michael L. McCartney and Alan F. Parr, US Patent #5,170,801, "Medical Capsule Device Actuated by Radio Frequency (RF) Signal", 15 December 1992.

Robert A. Casper, Warren J. Jochem, Michael L. McCartney and Alan F. Parr, US Patent #5,167,626, (Continutaion in Part of US Patent #5,170,801), "Medical Capsule Device actuated by Radio Frequency (RF) Signal", 1 December 1992.

Robert A. Casper, Frank A. Leith, David H. Leith, Malcolm B. Taylor, Maryann G. Bounty, (Application Filed), "MultiDose Dry Powder Inhalation Device".

Casper, R.A., Leith, F.A., and Gardner, D. L., "Dry Powder Medicament Inhalator Having an Inhalation- Activated Flow Diverting Means for Triggering
Delivery of Medicament", U.S. Patent #5,692,496, issued December 2, 1997.

Casper, R.A., Leith, F.A., and Gardner, D. L., "Dry Powder Medicament Inhalator Having an Inhalation- Activated Flow Diverting Means for Triggering Delivery of Medicament", U.S. Patent #5,823,183, issued October 20, 1998.

Casper, R.A., Leith, F.A., and Gardner, D. L., "Device for Use with Metered Dose Inhalers (MDIs)", U.S. Patent #5,826,571, issued October 27, 1998.

Casper, R.A., Leith, F.A., and Gardner, D. L., "Device for Use with Metered Dose Inhalers (MDIs)", WO 99/06091, issued February 11, 1999.

Casper, R.A., Leith, F.A., and Gardner, D. L., "Dry Powder Medicament Inhalator Having an Inhalation- Activated Flow Diverting Means for Triggering Delivery of Medicament", U.S. Patent #5,988,163, issued November 23, 1999.

Publications
Kelley, B.S.; Dunn, R.L.; Battistone, G.C.; Casper, R.A.; Vincent, J.W.; Borinski, R.A. Totally resorbable, high-strength glass/ceramic fibers for strengthening and reinforcing biodegradable composites. In: Knutson, K., ed. Transactions of the Twelfth Annual Meeting of the Society for Biomaterials; 1986 May 28-June 1; Minneapolis, MN. Society for Biomaterials; 1986: 167.

Casper, R.A.; Dunn, R.L.; Terry, R.N.; Beck, L.R. Development of a spermicide-releasing disposable barrier diaphragm. In: Anderson, J.M., ed. Transactions of the Second World Congress on Biomaterials; 1984 April 27-May 1; Washington, DC. Society for Biomaterials; 1984: 199.

Hollis, M.; Lemmons, J.; Nasca, R.; Casper, R.A. A biomechanical investigation of segmental and distraction spinal instruments. In: Anderson, J.M., ed. Transactions of the Second World Congress on Biomaterials; 1984 April 27-May 1; Washington, DC. Society for Biomaterials; 1984: 278.

Casper, R.A.; Dunn, R.L.; Kelley, B.S. Totally biodegradable fracture-fixation plates for use in maxillofacial surgery. In: Anderson, J.M., ed. Transactions of the Second World Congress on Biomaterials; 1984 April 27-May 1; Washington, DC. Society for Biomaterials; 1984: 278.

Stevens, J.D.S.; Casper, R.A.; Bhown, A.S.; Dunn, R.L., Development of a disposable spermicide-releasing diaphragm. In: Proceedings of the 11th International Symposium on Controlled Release of Bioactive Materials; 1984 July 23-25; Ft. Lauderdale, FL. Controlled Release Society, Inc.; 1984: 67-68.

Terry, R.N.; Dunn, R.L.; Casper, R.A; Cowsar, D.R. Development of a disposable, vaginal diaphragm with controlled release of spermicide. In: Proceedings of the 10th International Symposium on Controlled Release of Bioactive Materials; 1983 July 24-27; San Francisco, CA. Controlled Release Society, Inc.; 1983: 145-149.

Terry, R.N.; Dunn, R.L.; Casper, R.A.; Cowsar, D.R. Comparison of the mechanical properties of P-HEMA and P-HPMA hydrogels with a new synthetic polyamide hydrogel. In: Craig, R.G., ed. Transactions of the 9th Annual Meeting of the Society for Biomaterials; 1983 April 27-May 1; Birmingham, AL. Society for Biomaterials; 1983: 50.

Tice, T.R.; Lewis, D.H.; Dunn, R.L.; Meyers, W.E.; Casper, R.A.; Cowsar, D.R.; Beck, L.R. Biodegradation of microcapsules and biomedical devices prepared with resorbable polyesters. In: Kydonieus, A.F.; Langer, R.S., eds. Proceedings of the 9th International Symposium on Controlled Release of Bioactive Materials; 1982 July 26-28; Ft. Lauderdale, FL. Controlled Release Society, Inc., 1982: 21-25.

Dunn, R.L.; Casper, R.A.; Cowsar, D.R.; Lewis, D.H. Synthesis and properties of a new thermoplastic hydrogel. In: Spector, M., ed. Transactions of the 8th Annual Meeting of the Society for Biomaterials; 1982 April 24-27; Orlando, FL. Society for Biomaterials; 1982.

Casper, R.A.; Dunn, R.L.; Lewis, D.H. Characterization of new biomedical polymers as soft denture liners. Paper presented at the 60th General Session of the International Association for Dental Research. New Orleans, LA; 1982 March 18-21. [Abstract: J. Dent. Res. 61: 285; 1982.]

Lewis, D.H; Dunn, R.L.; Casper, R.A. Physical and mechanical properties of six commercial denture liners. Paper presented at the 60th General Session of the International Association for Dental Research. New Orleans, LA; 1982 March 12-21. [Abstract: J. Dent. Res. 61: 171; 1982.]

Dunn, R.L.; Casper, R.A.; Lewis, D.H. Strengthening biodegradable polymers for bone fixation and support. Paper presented at the 60th General Session of the International Association for Dental Research. New Orleans, LA; 1982 March 18-21. [Abstract: J. Dent. Res. 61: 171; 1982.]

Casper, R.A.; Dunn, R.L.; Lewis, D.H.; Fischer, T.F. A new aliphatic polyurethane for biomedical applications. In: Spector, M., ed. Transactions of the 8th annual Meeting of the Society for Biomaterials; 1982 April 24-27; Orlando, FL. Society for Biomaterials; 1982.

Dunn, R.L.; Casper, R.A.; Lewis, D.H. Absorbable fixation plates with fiber reinforcement. In: Beard, R.B., ed. Transactions of the 7th Annual Meeting of the Society for Biomaterials; 1981 May 28-31; Troy, NY. Society for Biomaterials; 1981.

Casper, R.A.; McElhaney, J.H. A one-dimensional viscoelastic model of the human lumbar disc. Paper presented at the 27th Annual Meeting of the Orthopedic Research Society. Las Vegas, NV; 1981 February 23-27.

Casper, R.A.; McElhaney, J.H. Relaxation response of the intervertebral motion unit. Paper presented at the 10th Annual Southeastern Conference for Theoretical and Applied Mechanics. Knoxville, TN; 1980 February 26-28.